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The Animal Use Protocol is the correct document that describes and justifies the use of animals for a research project. This protocol outlines the specific objectives of the research, the necessity of using animals, the ethical considerations involved, the species of animals to be used, the number of animals required, and the methods that will be employed to ensure their welfare and minimize pain and distress. It serves as a formal framework that must be approved before any animal research can commence, ensuring that the project adheres to regulatory standards and ethical guidelines.

While other documents, such as the IACUC Submission Form, may play a role in the approval process, they typically serve as part of the overall administrative framework rather than detailing the justifications and methodologies related to animal use. The Research Ethics Document may encompass broader ethical concerns related to research but does not specifically focus on the justification of animal use within a particular study. Therefore, the Animal Use Protocol is specifically tailored to address the criteria for using animals in research, making it the most appropriate answer.